Nitrazepam 10 mg is classified as a member of the benzodiazepine class of medicines. They are often reserved for the treatment of insomnia temporarily (as well as other sleeping problems such as regular night awakenings, early morning awakenings, and trouble falling asleep). Nitrazepam is a potent hypnotic medication that exhibits very potent sedative, anxiolytic, amnestic, and skeletal muscle relaxant effects. Mogadon is the brand name of this drug. The bioavailability ranges from 53 to 94%.

Mechanism Of Action

This medication affects central benzodiazepine receptors, which are linked to inhibitory GABA (gamma amino butyric acid) receptors. As a result, GABA binding activity is increased. GABA is an important neurotransmitter in the brain. Its effects include drowsiness, relaxing muscles, a reduction in anxious feelings, and a general sense of sadness across the central nervous system. The ability of nitrazepam 10 mg to bind to voltage-dependent sodium channels is likely responsible for the anticonvulsant effects of this drug. The impact of benzodiazepines, which is to slow down the recovery of sodium channels after they have been inactivated, appears to be a factor that limits sustained repeated firing.


Adults should take 5 mg once daily, with the ability to increase to 10 mg once daily if symptoms persist. It is recommended to take the doses before going to bed. The maximum time allowed for treatment is four weeks. Employ the smallest amount that is advised for the shortest period that is feasible.

Child: This is not recommended.

Elderly patients should take 2.5 mg once daily, possibly increasing to 5 mg once daily if necessary. It is recommended to take the doses before going to bed. Max: 5 mg daily. Employ the smallest dose advised for the shortest period that is feasible.


Talk to your primary care physician if you have a history of any medical condition, including but not limited to renal disease, liver illness, muscular issues, or allergies. Because nitrazepam 10 mg may produce drowsiness or dizziness, caution should be exercised if operating machinery or participating in activities that demand alertness, such as driving. When you are taking this medication, you should avoid drinking alcohol because it could make the symptoms of sleepiness and dizziness much worse.


Advise patients to avoid grapefruit juice and grapefruit during alprazolam medication. The combination of grapefruit juice and alprazolam should be avoided at all costs due to the risk of increased alprazolam concentrations, which can result in increased sedation for a longer time and respiratory depression. When used with opioids, there is a higher potential for sedation, depression of respiratory function, and coma. Increased depressive effects on the central nervous system when combined with centrally-acting agents (e.g. other hypnotics, neuroleptics, tranquillizers, antidepressants, nabilone). Rifampicin may lower the plasma concentration. Hydantoins or barbiturates may aggravate the harmful effects of this compound. Cimetidine may prevent nitrazepam from being metabolized properly.

How To Take This Medicine

Always listen to your physician’s advice regarding the correct dosage and the length of time you should take this medication. Nitrazepam 10mg Tablet may be used either with or without meals; nevertheless, it is recommended that you take the medication at the same time each day. Because of the potential for this prescription to cause addiction, the dosage should not be increased, nor should it be taken for a longer period than what is suggested. Even if you have been taking this drug for a considerable amount of time, you should not discontinue taking it without first obtaining authorization from your physician.

Missed dose:

If you forget to take your medication, take one Nitrazepam 10 mg Tablet as soon as you remember. However, if your next scheduled dose is coming up soon, you should omit the dose you missed and go back to your routine. Do not take two doses.


An overdose of nitrazepam can result in a range of symptoms, some of which include trouble breathing, dizziness, impaired cognition and balance, bluish nails and lips, slurred speech, and extreme drowsiness. These symptoms have the potential to develop into more serious diseases in the event of a severe overdose.


Nitrazepam 10 mg is a sedative drug so do not take it without the permission of the doctor as it may have some withdrawal symptoms so do not stop taking it by your own choice. Take the dose that is recommended by your physician otherwise, the effectiveness of this drug may decrease. 

Keep the medicine out of reach of the children and store it in a closed container away from light and moisture.

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